Borghi C, Boschi S, Costa F V, Munarini A, Mussi A, Ambrosioni E
Dept. of Clinical Pharmacology and Therapeutics, University of Bologna, Italy.
Am J Hypertens. 1988 Jul;1(3 Pt 1):294-7. doi: 10.1093/ajh/1.3.294.
Cardiopulmonary receptors influence renin release in a variety of physiological situations and in a fashion related to the degree of peripheral venous distensibility. We studied two groups of borderline hypertensives (BHTs) with different capacities to suppress plasma renin activity in response to saline infusion (0.20 mL/kg/per minute for 2 hours). Those BHTs with low suppressive capacity (L-supp) showed an increased venous distensibility in comparison with those with high suppressive capacity (H-supp). Saline infusion led to a significant increase in blood pressure only in L-supp BHTs, which was associated with enhanced 24-hour postloading natriuresis and raised plasma levels of an Na/K ATPase inhibitor (+12.2%). This result underlines the importance of venous distensibility as a determinant of pressor and humoral response to acute volume expansion.
心肺感受器在多种生理情况下会影响肾素释放，其方式与外周静脉扩张能力的程度有关。我们研究了两组临界高血压患者（BHT），这两组患者对生理盐水输注（0.20 mL/kg/分钟，持续2小时）抑制血浆肾素活性的能力不同。与高抑制能力（H-supp）的BHT相比，低抑制能力（L-supp）的BHT静脉扩张能力增强。生理盐水输注仅使L-supp BHT的血压显著升高，这与24小时负荷后利钠增加以及血浆中钠钾ATP酶抑制剂水平升高（+12.2%）有关。这一结果强调了静脉扩张能力作为急性容量扩张时压力和体液反应决定因素的重要性。
