Webb K B, Ayres S M, Mikes J, Evans R G
Department of Internal Medicine, St. Louis University School of Medicine, MO 63104.
Am J Prev Med. 1986 Mar-Apr;2(2):103-8.
The clinical recognition of dioxin-associated illness can be extremely difficult for the physician. After analyzing the relative sensitivity and specificity of reported manifestations of exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD), we suggest criteria for the diagnosis of dioxin toxicity. Exposure to higher doses of 2,3,7,8-TCDD may lead to the appearance of chloracne and the increased excretion of porphyrins and porphyria cutanea tarda. Liver function abnormalities, peripheral neuropathy, hyperlipidemia, and evidence of weakness and depression may occur following exposure; however, these findings are less specific since diseases such as diabetes or alcoholism could cause several of these problems. The long-term effects of exposure to low-dose TCDD are currently uncertain.
对于医生而言，二噁英相关疾病的临床识别可能极其困难。在分析了所报告的2,3,7,8 - 四氯二苯并 - 对 - 二噁英（TCDD）暴露表现的相对敏感性和特异性后，我们提出了二噁英毒性的诊断标准。接触较高剂量的2,3,7,8 - TCDD可能会导致氯痤疮的出现以及卟啉排泄增加和迟发性皮肤卟啉症。接触后可能会出现肝功能异常、周围神经病变、高脂血症以及虚弱和抑郁的迹象；然而，这些发现的特异性较低，因为糖尿病或酒精中毒等疾病也可能导致其中一些问题。目前，低剂量TCDD暴露的长期影响尚不确定。
