[同种异体抗原耐受性中移植物抗移植物反应的抑制因子]
[Suppressors of the graft vs graft reaction in tolerance to alloantigens].
作者信息
Cherniakhovskaia I Iu, Prigozhina T B, Nagurskaia E V, Fontalin L N
出版信息
Biull Eksp Biol Med. 1988 Jun;105(6):697-700.
Immune response and suppressor cell activity of CBA (H-2k) mice made tolerant to allogeneic C57B1/6 (H-2b) heart graft were studied in graft-versus-graft reaction (GvGR). Intact CBA spleen cells inhibited response of (CBA X C57B1/6)F1 cells to antigenic stimulus (sheep red blood cells--SRBC), when injected together into lethally irradiated (CBA X C57B1/6)F1 mice. Spleen cells of tolerant mice were unable to decrease immune response of (CBA X C57B1/6F1 lymphocytes to SRBC and suppressed specifically the inhibition induced by intact CBA spleen cells. Spleen cells from tolerant mice were also capable of suppressing GvGR induced by CBA lymphocytes immune to C57B1/6 cells. Pretreatment of tolerant spleen cells with rabbit antithymocyte globulin and complement before adoptive transfer diminished markedly the suppression. The results obtained in the study suggest that suppression of transplantation immunity in this model is mostly due to T suppressor cells.
在移植物抗移植物反应（GvGR）中研究了对同种异体C57B1/6（H-2b）心脏移植物产生耐受的CBA（H-2k）小鼠的免疫反应和抑制细胞活性。当完整的CBA脾细胞与（CBA×C57B1/6）F1细胞一起注射到经致死剂量照射的（CBA×C57B1/6）F1小鼠体内时，CBA脾细胞抑制了（CBA×C57B1/6）F1细胞对抗抗原刺激（绵羊红细胞——SRBC）的反应。耐受小鼠的脾细胞无法降低（CBA×C57B1/6）F1淋巴细胞对SRBC的免疫反应，且特异性地抑制了完整CBA脾细胞诱导的抑制作用。来自耐受小鼠的脾细胞也能够抑制由对C57B1/6细胞免疫的CBA淋巴细胞诱导的GvGR。在过继转移前用兔抗胸腺细胞球蛋白和补体对耐受脾细胞进行预处理，可显著减弱这种抑制作用。该研究获得的结果表明，在这个模型中移植免疫的抑制主要归因于T抑制细胞。
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