Cherniakhovskaia I Iu, Nagurskaia E V, Shaposhnikova G B, Fontalin L N
Biull Eksp Biol Med. 1980 Mar;89(3):320-2.
The tolerance to allogeneic C57BL/6 cells (H--2b) was induced in adult CBA mice (H--2k). For tolerance induction three kinds of treatment were combined: thymectomy of adult CBA mice, intravenous inoculation of 1 x 10(8) spleen C57BL/6 cells and injection of 200 mg/kg of cyclophosphamide after 24 hours. Such a treatment of CBA mice resulted in long survival (up to 5 months) of allogeneic C57BL/L heart grafts. The data obtained in MLC reaction supported unresponsiveness of tolerant CBA mice to H-2 antigens of C57BL/6 mice. No lymphoid tissue chimerism was observed in tolerant mice.
在成年CBA小鼠（H-2k）中诱导对同种异体C57BL/6细胞（H-2b）的耐受性。为诱导耐受性，采用了三种处理方法相结合：成年CBA小鼠胸腺切除术、静脉注射1×10⁸个C57BL/6脾细胞，并在24小时后注射200mg/kg环磷酰胺。对CBA小鼠的这种处理使得同种异体C57BL/L心脏移植物长期存活（长达5个月）。混合淋巴细胞培养反应获得的数据支持了耐受性CBA小鼠对C57BL/6小鼠H-2抗原无反应。在耐受性小鼠中未观察到淋巴组织嵌合现象。
