[Induction of tolerance to alloantigens in adult mice].

The tolerance to allogeneic C57BL/6 cells (H--2b) was induced in adult CBA mice (H--2k). For tolerance induction three kinds of treatment were combined: thymectomy of adult CBA mice, intravenous inoculation of 1 x 10(8) spleen C57BL/6 cells and injection of 200 mg/kg of cyclophosphamide after 24 hours. Such a treatment of CBA mice resulted in long survival (up to 5 months) of allogeneic C57BL/L heart grafts. The data obtained in MLC reaction supported unresponsiveness of tolerant CBA mice to H-2 antigens of C57BL/6 mice. No lymphoid tissue chimerism was observed in tolerant mice.