Goubran F, Maklady F
Clinical Pathology Department, Suez Canal Medical School, Ismailia, Egypt.
Blut. 1988 Jul;57(1):15-7. doi: 10.1007/BF00320629.
To clarify the relationship between serum albumin concentration and in vivo platelet activity in nephrotic syndrome, Beta-thromboglobulin (B-TG) levels and circulating platelet aggregation ratio (PAR) were determined in 25 nephrotic patients. PAR levels were significantly decreased compared with the controls and showed a positive correlation with serum albumin concentrations. The values of B-TG were high in all nephrotic patients and showed an inverse relationship with serum albumin levels. In addition, increased B-TG levels correlated with decreased PAR values. Therefore serum albumin plays a regulatory role in the activity of circulating platelets in the nephrotic syndrome. Prospective longitudinal studies must be done to elucidate the usefulness of platelet inhibitors as a prophylactic therapy of intravascular thrombosis in nephrotic patients.
为阐明肾病综合征患者血清白蛋白浓度与体内血小板活性之间的关系，我们测定了25例肾病患者的β-血小板球蛋白（B-TG）水平和循环血小板聚集率（PAR）。与对照组相比，PAR水平显著降低，且与血清白蛋白浓度呈正相关。所有肾病患者的B-TG值均较高，且与血清白蛋白水平呈负相关。此外，B-TG水平升高与PAR值降低相关。因此，血清白蛋白在肾病综合征患者循环血小板活性中起调节作用。必须进行前瞻性纵向研究，以阐明血小板抑制剂作为肾病患者血管内血栓形成预防性治疗方法的有效性。
