Pour P M, Redding T W, Paz-Bouza J I, Schally A V
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68105-1065.
Cancer Lett. 1988 Jul;41(1):105-10. doi: 10.1016/0304-3835(88)90061-4.
Hormones, particularly gonadotropins, have been implicated in the development of ovarian cancer. Chronic administration of agonistic analogs of luteinizing-hormone releasing-hormone (LH-RH) induces an inhibition of the pituitary-gonadal axis. The blockade of the release of luteinizing-hormone and follicle-stimulating hormone (FSH) may exert a possible therapeutic effect on ovarian cancer. We examined the results of prolonged administration of D-Trp-6-LH-RH, an agonistic analog of LH-RH in experimental ovarian cancer. We used the recently developed ovarian cancer model in rats, which is produced by treatment of pregnant rats with N-nitrosobis(2-oxopropyl)amine (BOP), following which a high incidence of ovarian tumors are induced in the offspring. In morphologic aspects the induced tumor resembles human ovarian neoplasms. Once a month administration of a delayed release preparation of microcapsules of D-Trp-6-LH-RH prolonged the survival and decreased tumor growth and the incidence of metastases. Additional experimental and clinical studies are needed to determine the efficacy of the treatment with LH-RH analogs in ovarian cancer.
激素，尤其是促性腺激素，被认为与卵巢癌的发生有关。长期给予促黄体生成素释放激素（LH-RH）的激动剂类似物会抑制垂体-性腺轴。促黄体生成素和促卵泡激素（FSH）释放的阻断可能对卵巢癌产生潜在的治疗作用。我们研究了在实验性卵巢癌中长时间给予D-色氨酸-6-LH-RH（一种LH-RH激动剂类似物）的结果。我们使用了最近在大鼠中建立的卵巢癌模型，该模型是通过用N-亚硝基双（2-氧代丙基）胺（BOP）处理怀孕大鼠而产生的，随后其后代中会诱导出高发病率的卵巢肿瘤。在形态学方面，诱导产生的肿瘤类似于人类卵巢肿瘤。每月一次给予D-色氨酸-6-LH-RH微胶囊缓释制剂可延长生存期，并减少肿瘤生长和转移发生率。需要更多的实验和临床研究来确定LH-RH类似物治疗卵巢癌的疗效。
