Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA.
TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX 77843, USA.
Database (Oxford). 2018 Jan 1;2018. doi: 10.1093/database/bay012.
Cold-induced thermogenesis increases energy expenditure and can reduce body weight in mammals, so the genes involved in it are thought to be potential therapeutic targets for treating obesity and diabetes. In the quest for more effective therapies, a great deal of research has been conducted to elucidate the regulatory mechanism of cold-induced thermogenesis. Over the last decade, a large number of genes that can enhance or suppress cold-induced thermogenesis have been discovered, but a comprehensive list of these genes is lacking. To fill this gap, we examined all of the annotated human and mouse genes and curated those demonstrated to enhance or suppress cold-induced thermogenesis by in vivo or ex vivo experiments in mice. The results of this highly accurate and comprehensive annotation are hosted on a database called CITGeneDB, which includes a searchable web interface to facilitate broad public use. The database will be updated as new genes are found to enhance or suppress cold-induced thermogenesis. It is expected that CITGeneDB will be a valuable resource in future explorations of the molecular mechanism of cold-induced thermogenesis, helping pave the way for new obesity and diabetes treatments. Database URL: http://citgenedb.yubiolab.org.
冷诱导产热可增加能量消耗，并可降低哺乳动物的体重，因此，人们认为参与其中的基因是治疗肥胖症和糖尿病的潜在治疗靶点。为了寻求更有效的治疗方法，人们进行了大量研究来阐明冷诱导产热的调节机制。在过去的十年中，已经发现了大量可以增强或抑制冷诱导产热的基因，但缺乏这些基因的综合列表。为了填补这一空白，我们检查了所有注释的人类和小鼠基因，并对通过体内或体外实验在小鼠中证明可增强或抑制冷诱导产热的基因进行了编辑。该高度准确和全面注释的结果托管在一个名为 CITGeneDB 的数据库中，该数据库包含一个可搜索的网络界面，以方便广泛的公众使用。随着发现新的增强或抑制冷诱导产热的基因，该数据库将不断更新。预计 CITGeneDB 将成为未来探索冷诱导产热分子机制的宝贵资源，为新的肥胖症和糖尿病治疗方法铺平道路。数据库 URL：http://citgenedb.yubiolab.org。
