Lönn U, Lönn S
Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Cancer Res. 1988 Aug 1;48(15):4153-7.
Leucovorin augments the growth inhibitory effect of 5-fluoropyrimidines on neoplastic cells. The effect is paralleled by much higher levels of DNA fragmentation than in cells treated with 5-fluoropyrimidines alone at the same concentration. The lesions are induced by a mechanism independent of incorporation of the drug into DNA, in all probability due to reduced repair of DNA lesions induced independently of the drug treatment. Thymidine added after the treatment with fluoropyrimidines partly rescues the cells and reduces the level of DNA fragmentation.
亚叶酸增强了 5-氟嘧啶对肿瘤细胞的生长抑制作用。与在相同浓度下仅用 5-氟嘧啶处理的细胞相比，这种作用伴随着更高水平的 DNA 片段化。这些损伤是由一种独立于药物掺入 DNA 的机制诱导的，很可能是由于药物治疗独立诱导的 DNA 损伤修复减少。在用氟嘧啶处理后添加胸苷可部分挽救细胞并降低 DNA 片段化水平。
