From the Departments of Nuclear Medicine and PET/CT, and.
Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Clin Nucl Med. 2018 Jul;43(7):529-532. doi: 10.1097/RLU.0000000000002103.
PET/CT with Ga-labeled prostate-specific membrane antigen (PSMA) is increasingly recognized as the best imaging modality for disease staging and detection of recurrent prostate cancer. Despite its name, PSMA expression has been reported in a number of nonprostatic benign and malignant pathologies. Apparently, angioneogenesis is the mechanism attributed to increased Ga-PSMA uptake at these sites. Here we illustrate the utility of Ga-PSMA in 5 nonprostatic malignancies that could open up new possibilities for diagnostics and theranostic concepts with PSMA labeled radioligands in nonprostate tumor entities.
正电子发射断层扫描/计算机断层扫描（PET/CT）结合 Ga 标记的前列腺特异性膜抗原（PSMA），越来越被认为是疾病分期和检测复发性前列腺癌的最佳成像方式。尽管名称如此，但 PSMA 表达已在许多非前列腺良性和恶性病变中得到报道。显然，血管生成是导致这些部位 Ga-PSMA 摄取增加的机制。在这里，我们举例说明了 Ga-PSMA 在 5 种非前列腺恶性肿瘤中的应用，这为 PSMA 标记放射性配体在非前列腺肿瘤实体中的诊断和治疗概念开辟了新的可能性。
