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在镓-68 PSMA PET/CT成像上检测多西他赛诱导的间质性肺炎

Detection of Docetaxel-induced Interstitial Pneumonitis on Ga-68 PSMA PET/CT Imaging.

作者信息

Meena Anjali, Mittal Bhagwant Rai, Singh Harmandeep, Bora Girdhar S, Kumar Rajender

机构信息

Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Indian J Nucl Med. 2024 May-Jun;39(3):220-221. doi: 10.4103/ijnm.ijnm_147_23. Epub 2024 Aug 17.

DOI:10.4103/ijnm.ijnm_147_23
PMID:39291078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11404741/
Abstract

Ga-68 labeled prostate-specific membrane antigen (PSMA) positron emission tomography-computed tomography (PET/CT) is increasingly recognized as the best imaging modality for disease staging and detection of recurrent prostate cancer. Despite its name, PSMA expression has been reported in the neovasculature of several nonprostatic benign and malignant pathologies. Docetaxel, a taxane antineoplastic agent, is the mainstay of treatment in castration-resistant prostate cancer and high-volume hormone-sensitive prostate cancer. Although the occurrence of docetaxel-related interstitial lung disease is rare, it may lead to respiratory failure if treatment is delayed. We present a case of metastatic castration-resistant prostate cancer, wherein docetaxel-induced interstitial pneumonitis was detected on Ga-68 PSMA PET/CT after docetaxel administration.

摘要

镓-68标记的前列腺特异性膜抗原（PSMA）正电子发射断层扫描-计算机断层扫描（PET/CT）越来越被认为是疾病分期和复发性前列腺癌检测的最佳成像方式。尽管其名称如此，但已有报道称PSMA在几种非前列腺良性和恶性病变的新生血管中表达。多西他赛是一种紫杉烷类抗肿瘤药物，是去势抵抗性前列腺癌和高负荷激素敏感性前列腺癌治疗的主要药物。虽然多西他赛相关的间质性肺病发生率很低，但如果治疗延迟可能会导致呼吸衰竭。我们报告一例转移性去势抵抗性前列腺癌病例，该病例在给予多西他赛后，通过镓-68 PSMA PET/CT检测到多西他赛诱导的间质性肺炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bf0/11404741/7231d42ca10a/IJNM-39-220-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bf0/11404741/7231d42ca10a/IJNM-39-220-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bf0/11404741/7231d42ca10a/IJNM-39-220-g001.jpg

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Clin Nucl Med. 2021 May 1;46(5):e268-e269. doi: 10.1097/RLU.0000000000003445.
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68Ga-Prostate-Specific Membrane Antigen PET/CT and 18F-FDG PET/CT of Primary Signet Ring Cell Breast Adenocarcinoma.前列腺特异性膜抗原 PET/CT 与 18F-FDG PET/CT 对原发性印戒细胞乳腺癌的诊断价值。
Clin Nucl Med. 2018 Nov;43(11):e414-e416. doi: 10.1097/RLU.0000000000002265.
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68Ga-Labeled PSMA Uptake in Nonprostatic Malignancies: Has the Time Come to Remove "PS" From PSMA?68Ga 标记的 PSMA 摄取在非前列腺恶性肿瘤中的应用：是否到了从 PSMA 中去除“PS”的时候了？
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