Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark; Department of Gynaecology and Obstetrics, Odense University Hospital, Odense, Denmark.
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.
Diabetes Res Clin Pract. 2018 Nov;145:167-177. doi: 10.1016/j.diabres.2018.04.030. Epub 2018 Apr 22.
Insulin resistance is common in polycystic ovary syndrome (PCOS). PCOS may be associated with increased risk of gestational diabetes mellitus (GDM).
To (1) review literature regarding PCOS and hyperglycaemia in pregnancy and (2) present original data from Odense Child Cohort (OCC) regarding GDM in PCOS.
Literature search including original studies from 2000-18. OCC included 2548 pregnant women, 9.5% (n = 241) had PCOS. Fasting plasma glucose was measured in 1519 and 659 oral glucose tolerance tests were performed (with risk factor for GDM, n = 384, without risk factors, n = 275), applying two different GDM criteria.
30 studies were eligible using 12 different sets of diagnostic criteria for GDM. Ten studies included n > 50, control group, assessment of GDM and BMI. Results were not uniform, but supported that higher BMI, higher age, Asian ethnicity, and fertility treatment increased the risk of GDM in PCOS. In OCC, women with PCOS and controls had similar prevalences of GDM independent of different sets of criteria for GDM.
PCOS may not be an individual risk factor for GDM. Pregnancies in PCOS are characterized by factors known to increase risk of GDM, especially high BMI and fertility treatment.
胰岛素抵抗在多囊卵巢综合征（PCOS）中很常见。PCOS 可能与妊娠糖尿病（GDM）风险增加有关。
（1）综述有关 PCOS 和妊娠期间高血糖的文献，（2）介绍奥登塞儿童队列（OCC）中关于 PCOS 中 GDM 的原始数据。
文献检索包括 2000-18 年的原始研究。OCC 纳入了 2548 名孕妇，其中 9.5%（n=241）患有 PCOS。1519 名孕妇测量了空腹血糖，659 名孕妇进行了口服葡萄糖耐量试验（有 GDM 危险因素，n=384，无危险因素，n=275），应用了两种不同的 GDM 标准。
使用 12 种不同的 GDM 诊断标准，有 30 项研究符合条件。10 项研究纳入 n>50 例，对照组，评估 GDM 和 BMI。结果不一致，但支持更高的 BMI、更高的年龄、亚洲种族和生育治疗增加了 PCOS 中 GDM 的风险。在 OCC 中，患有 PCOS 和对照组的女性无论 GDM 的标准如何，GDM 的患病率相似。
PCOS 可能不是 GDM 的个体危险因素。PCOS 妊娠的特点是已知增加 GDM 风险的因素，尤其是高 BMI 和生育治疗。
