Palm Camilla V B, Glintborg Dorte, Find Laura G, Larsen Pia V, Dalgaard Cilia M, Boye Henriette, Jensen Tina K, Dreyer Anja F, Andersen Marianne S, Bilenberg Niels
Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 12C, 5000, Odense, Denmark.
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Winsløwsparken 19, 3rd floor, 5000, Odense, Denmark.
J Autism Dev Disord. 2023 Mar;53(3):1053-1065. doi: 10.1007/s10803-022-05446-w. Epub 2022 Feb 6.
Fetal androgen exposure may be associated with autism spectrum disorder (ASD). We studied 1777 mother-child pairs in the prospective Odense Child Cohort. Prenatal androgen exposure was assessed by maternal 3rd trimester testosterone concentrations, maternal polycystic ovary syndrome (PCOS), and 3 months offspring anogenital distance. ASD traits were assessed at age 3 years with the ASD-symptom scale of the Child Behavior Checklist for ages 1½-5 years. Maternal testosterone was positively associated with traits of ASD in boys (p < 0.05). Maternal PCOS was associated with increased offspring ASD traits (p = 0.046), but became non-significant after excluding parental psychiatric diagnosis. Offspring anogenital distance was not linked to ASD traits. Higher prevalence of ASD in boys could be linked to higher susceptibility to fetal androgen exposure.
胎儿期雄激素暴露可能与自闭症谱系障碍（ASD）有关。我们在奥登塞前瞻性儿童队列中研究了1777对母婴。通过母亲孕晚期睾酮浓度、母亲多囊卵巢综合征（PCOS）以及3个月大后代的肛殖距来评估产前雄激素暴露情况。在孩子3岁时，使用1.5 - 5岁儿童行为检查表的ASD症状量表来评估ASD特征。母亲的睾酮水平与男孩的ASD特征呈正相关（p < 0.05）。母亲患PCOS与后代ASD特征增加有关（p = 0.046），但在排除父母精神疾病诊断后变得不显著。后代的肛殖距与ASD特征无关。男孩中较高的ASD患病率可能与胎儿期雄激素暴露的易感性较高有关。
