Kohno Milky, Loftis Jennifer M, Huckans Marilyn, Dennis Laura E, McCready Holly, Hoffman William F
Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, USA; Research & Development Service, Veterans Affairs Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, USA; Methamphetamine Abuse Research Center, Oregon Health & Science University and Veterans Affairs Portland Health Care System, Portland, OR, USA.
Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, USA; Research & Development Service, Veterans Affairs Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, USA; Northwest Hepatitis C Resource Center, Veterans Affairs Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, USA; Methamphetamine Abuse Research Center, Oregon Health & Science University and Veterans Affairs Portland Health Care System, Portland, OR, USA.
Neurosci Lett. 2018 Jun 11;677:49-54. doi: 10.1016/j.neulet.2018.04.037. Epub 2018 Apr 22.
Methamphetamine (MA) causes an increase in pro-inflammatory cytokines in animal models and in humans. Resulting activation of microglia and neuro-inflammation could, via effects on reward networks, mediate behavioral characteristics of addiction. We examined the relationship between interleukin-6 (IL-6) and corticolimbic and striatolimbic resting-state functional connectivity (RSFC). Thirty adults diagnosed with MA dependence and 20 control subjects underwent a resting-state functional magnetic resonance imaging (fMRI) scan and gave a blood sample for determination of plasma IL-6 levels. Seed-based RSFC analyses were performed to examine the interactive effect of group and IL-6 on ventral striatal and prefrontal connectivity. Within the MA group, IL-6 levels were positively related to striatolimbic RSFC but negatively related to corticostriatal RSFC. Our findings with IL-6 support the idea that inflammation may at least partly mediate the link among MA use disorder, RSFC, and behavior, possibly via effects on mesolimbic and mesocortical dopaminergic systems.
甲基苯丙胺（MA）在动物模型和人类中会导致促炎细胞因子增加。由此引发的小胶质细胞激活和神经炎症可能通过对奖赏网络的影响，介导成瘾的行为特征。我们研究了白细胞介素-6（IL-6）与皮质边缘和纹状体边缘静息态功能连接（RSFC）之间的关系。30名被诊断为MA依赖的成年人和20名对照受试者接受了静息态功能磁共振成像（fMRI）扫描，并提供血样以测定血浆IL-6水平。进行了基于种子点的RSFC分析，以检验组和IL-6对腹侧纹状体和前额叶连接性的交互作用。在MA组中，IL-6水平与纹状体边缘RSFC呈正相关，但与皮质纹状体RSFC呈负相关。我们关于IL-6的研究结果支持这样一种观点，即炎症可能至少部分介导了MA使用障碍、RSFC和行为之间的联系，可能是通过对中脑边缘和中脑皮质多巴胺能系统的影响。
