Department of Obstetrics, Department of Internal Medicine and Endocrinology Lab Platform, Medical University Graz, Graz, Austria.
Department of Obstetrics, Department of Internal Medicine and Endocrinology Lab Platform, Medical University Graz, Graz, Austria.
J Reprod Immunol. 2018 Jun;127:19-23. doi: 10.1016/j.jri.2018.04.002. Epub 2018 Apr 18.
An imbalance of angiogenic placental factors such as endoglin, soluble fms-like tyrosine kinase 1(sFlt-1) and placental growth factor (PlGF) has been implicated in the pathophysiology of preeclampsia. This study aimed to evaluate serum levels of sFlt-1, PlGF and endoglin in women with primary and secondary antiphospholipid Syndrome (APS) and systemic lupus erythematosus (SLE) longitudinally through pregnancy.
Serum levels of sFlt-1, PlGF and endoglin were measured prospectively at 4-week intervals (from gestational weeks 12-36) in 17 women with primary APS (PAPS), 18 women with secondary APS (SAPS), and 23 women with SLE.
6/17 (35%) of women with PAPS, 3/18 (17%) of women with SAPS, and 2/23 (9%) of women with SLE developed early-onset preeclampsia. Women who developed preeclampsia had significantly higher mean sFlt-1 and endoglin levels, higher sFlt-1/PlGF ratios, and lower mean PlGF-levels than women who did not. These changes became statistically significant at 12 weeks for sFlt-1, PlGF and endoglin.
Endoglin, sFlt-1 and PlGF are potential early screening parameters for the development of preeclampsia in pregnant women with autoimmune diseases like APS and SLE.
血管生成胎盘因子（如内皮糖蛋白、可溶性 fms 样酪氨酸激酶 1（sFlt-1）和胎盘生长因子（PlGF））的失衡与子痫前期的病理生理学有关。本研究旨在通过妊娠期间的纵向研究，评估原发性和继发性抗磷脂综合征（APS）和系统性红斑狼疮（SLE）妇女的血清 sFlt-1、PlGF 和内皮糖蛋白水平。
前瞻性地测量了 17 名原发性 APS（PAPS）、18 名继发性 APS（SAPS）和 23 名 SLE 妇女在 4 周间隔（从妊娠 12-36 周）的血清 sFlt-1、PlGF 和内皮糖蛋白水平。
6/17（35%）名 PAPS 妇女、3/18（17%）名 SAPS 妇女和 2/23（9%）名 SLE 妇女发生早发型子痫前期。发生子痫前期的妇女的平均 sFlt-1 和内皮糖蛋白水平显著升高，sFlt-1/PlGF 比值更高，PlGF 水平更低。这些变化在 12 周时对于 sFlt-1、PlGF 和内皮糖蛋白变得具有统计学意义。
内皮糖蛋白、sFlt-1 和 PlGF 是 APS 和 SLE 等自身免疫性疾病孕妇子痫前期发展的潜在早期筛查参数。
