生长因子 1 水平降低与小于胎龄儿的舒张性心脏功能障碍有关。

Decreased Circulating Insulin-Like Growth Factor 1 Levels Are Associated with Cardiac Diastolic Dysfunction in Small for Gestational Age Infants.

机构信息

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.

Division of Neonatology, Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.

出版信息

Am J Perinatol. 2018 Oct;35(12):1178-1185. doi: 10.1055/s-0038-1642060. Epub 2018 Apr 24.

DOI:10.1055/s-0038-1642060

PMID:29689577

Abstract

OBJECTIVE

To evaluate the impact of serum insulin-like growth factor-1 (IGF-1) levels on cardiac function in small for gestational age (SGA) infants.

STUDY DESIGN

This is a prospective, observational study. Serum IGF-1 levels at birth and echocardiography measurements at 1 week of age were compared between SGA and appropriate for gestational age (AGA) infants.

RESULTS

Thirty-one SGA infants and 27 AGA infants were enrolled. Serum IGF-1 levels were lower in the SGA infants than in the AGA infants. SGA infants had lower mitral lateral annular systolic (S') and early diastolic (E') tissue Doppler imaging velocities compared with AGA infants (S', 5.1 ± 0.9 vs 5.7 ± 1.2 cm/s; E', 6.1 ± 1.5 cm/s vs 7.1 ± 1.3 cm/s; < 0.05). Serum IGF-1 levels positively correlated with E' velocity in the entire population ( = 0.44, < 0.001) and in SGA infants ( = 0.39, < 0.05). In multivariate linear regression analysis, serum IGF-1 and S' velocity were independently associated with E' velocity in the entire population and in SGA infants.

CONCLUSION

Decreased serum IGF-I levels could account for cardiac diastolic dysfunction in SGA infants.

摘要

目的

评估血清胰岛素样生长因子-1（IGF-1）水平对小于胎龄儿（SGA）心脏功能的影响。

研究设计

这是一项前瞻性观察性研究。比较了 SGA 和适于胎龄（AGA）婴儿出生时的血清 IGF-1 水平和 1 周龄时的超声心动图测量值。

结果

共纳入 31 例 SGA 婴儿和 27 例 AGA 婴儿。SGA 婴儿的血清 IGF-1 水平低于 AGA 婴儿。与 AGA 婴儿相比，SGA 婴儿的二尖瓣外侧环收缩期（S'）和舒张早期（E'）组织多普勒成像速度较低（S'：5.1 ± 0.9 对 5.7 ± 1.2 cm/s；E'：6.1 ± 1.5 cm/s 对 7.1 ± 1.3 cm/s； < 0.05）。血清 IGF-1 水平与整个研究人群的 E'速度呈正相关（ = 0.44， < 0.001），与 SGA 婴儿也呈正相关（ = 0.39， < 0.05）。多元线性回归分析显示，血清 IGF-1 和 S'速度与整个研究人群和 SGA 婴儿的 E'速度独立相关。