胰岛素抵抗对小于胎龄儿胰岛素样生长因子-1/胰岛素样生长因子结合蛋白-3轴及早期体重增加的影响。

Impact of insulin resistance on insulin-like growth factor-1/insulin like growth factor-binding protein-3 axis and on early weight gain in small for gestational age infants.

作者信息

Dizdarer Ceyhun, Korkmaz Hüseyin Anıl, Büyükocak Özlem Murat, Tarancı Selda Mohan, Coban Ayşe

机构信息

Dr. Behçet Uz Children Disease and Surgery Training and Research Hospital, Department of Pediatric Endocrinology, İzmir, Turkey.

出版信息

J Clin Res Pediatr Endocrinol. 2013;5(2):104-9. doi: 10.4274/Jcrpe.867.

DOI:10.4274/Jcrpe.867

PMID:23748063

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3701915/

Abstract

OBJECTIVE

To assess insulin-like growth factor-1 (IGF-1)/IGF-binding protein-3 (IGFBP-3) axis and insulin resistance (IR) and the relationship of these parameters with growth in appropriate for gestational age (AGA) and small for gestational age (SGA) infants at birth and in early infancy.

METHODS

Postnatal blood samples for measurement of glucose, insulin, IGF-1, and IGFBP-3 were taken from 60 infants (30 AGA and 30 SGA) at birth and at one, three, and six months of age. Both SGA and AGA infants were divided into two groups: growing well and not growing well. Blood glucose, insulin, IGF-1, and IGFBP-3 values were assessed in all infants.

RESULTS

Homeostasis model assessment-IR (HOMA-IR) values in well-growing SGA infants in the third and sixth months were found to be higher than in not well-growing SGA infants (3.9±0.8 vs. 1.0±0.3 at 3 months and 3.3±0.9 vs. 2.4±0.9 at 6 months, p<0.05). IGF-1 levels in well-growing SGA infants at 3 and 6 months were found to be higher than those in not well-growing SGA infants (83.80±44.50 vs. 73.50±17.60 ng/mL at 3 months and 95.12±50.74 vs. 87.67±22.91 ng/mL at 6 months, p<0.05). The IGF-1 values were significantly lower in well-growing SGA infants than in well-growing AGA infants (83.80±44.50 vs. 103.31±30.81 ng/mL at 3 months and 95.12±50.74 vs. 110.87±26.44 ng/mL at 6 months, p<0.05).

CONCLUSIONS

This study demonstrates the effects of accelerated early infant growth on IGF-1/IGFBP-3 axis in SGA-born infants.

摘要

目的

评估胰岛素样生长因子-1（IGF-1）/胰岛素样生长因子结合蛋白-3（IGFBP-3）轴及胰岛素抵抗（IR），以及这些参数与适于胎龄（AGA）和小于胎龄（SGA）婴儿出生时及婴儿早期生长的关系。

方法

在出生时以及出生后1个月、3个月和6个月，采集60例婴儿（30例AGA和30例SGA）的产后血样，用于检测血糖、胰岛素、IGF-1和IGFBP-3。SGA和AGA婴儿均分为两组：生长良好组和生长不佳组。评估所有婴儿的血糖、胰岛素、IGF-1和IGFBP-3值。

结果

发现生长良好的SGA婴儿在3个月和6个月时的稳态模型评估-IR（HOMA-IR）值高于生长不佳的SGA婴儿（3个月时为3.9±0.8 vs. 1.0±0.3，6个月时为3.3±0.9 vs. 2.4±0.9，p<0.05）。发现生长良好的SGA婴儿在3个月和6个月时的IGF-1水平高于生长不佳的SGA婴儿（3个月时为83.80±44.50 vs. 73.50±17.60 ng/mL，6个月时为95.12±50.74 vs. 87.67±22.91 ng/mL，p<0.05）。生长良好的SGA婴儿的IGF-1值显著低于生长良好的AGA婴儿（3个月时为83.80±44.50 vs. 103.31±30.81 ng/mL，6个月时为95.12±50.74 vs. 110.87±26.44 ng/mL，p<0.05）。