Ohshima H
Department of Neuropsychiatry, Kurume University School of Medicine.
Jpn J Psychiatry Neurol. 1987 Dec;41(4):645-50. doi: 10.1111/j.1440-1819.1987.tb00421.x.
Seven patients with sleep apnea DOES and one with sleep apnea DIMS were treated with medroxyprogesterone acetate (MPA). The therapeutic effect was confirmed in most of them by polysomnographic recording. A marked increase of TST was observed in two patients whose AI and/or %SAT remarkably decreased. Contrarily, three patients exhibited a considerable decrease in TST, and AI and/or %SAT were reduced remarkably in two of them with MPA. After the MPA medication a few patients complained of disturbed nocturnal sleep. A significant positive correlation was observed between the decreased rate of TST and that of the mean duration of apneas. From these results, it was considered that MPA has a mild activating action on the arousal system in the CNS, and that the action may be partly responsible for the therapeutic effects of MPA on sleep apneas.
7例阻塞性睡眠呼吸暂停（DOES）患者和1例混合性睡眠呼吸暂停（DIMS）患者接受了醋酸甲羟孕酮（MPA）治疗。多数患者的治疗效果通过多导睡眠图记录得以证实。2例患者的总睡眠时间（TST）显著增加，其呼吸暂停指数（AI）和/或血氧饱和度（%SAT）明显降低。相反，3例患者的TST显著减少，其中2例患者使用MPA后AI和/或%SAT明显降低。服用MPA后，少数患者抱怨夜间睡眠受到干扰。TST降低率与平均呼吸暂停持续时间降低率之间存在显著正相关。从这些结果来看，认为MPA对中枢神经系统的唤醒系统有轻度激活作用，且该作用可能部分是MPA对睡眠呼吸暂停治疗效果的原因。
