Kotorii T, Nonaka K, Nakazawa Y, Matsunaga H, Mieno K, Hatase T, Kodama H, Nishida T
Department of Neuropsychiatry, Kurume University School of Medicine, Japan.
Jpn J Psychiatry Neurol. 1987 Jun;41(2):261-7. doi: 10.1111/j.1440-1819.1987.tb00410.x.
The effects of a single 100 mg dose of medroxyprogesterone acetate (MPA) on human sleep were investigated using healthy young male adults. After a baseline night recording, two consecutive MPA nights and the following two withdrawal nights were recorded. The total sleep time was reduced after the 2nd MPA night and the decrease was significant on the 1st withdrawal night. The time of intrasleep awakening increased after the 2nd MPA night. Stage 1 sleep increased significantly on the 2nd MPA and 1st withdrawal nights. Stage 4 sleep decreased and the sleep latency gradually increased after the MPA administration. REM sleep reduced slightly on the 1st withdrawal night. These results indicate that MPA has a mild arousal action on human sleep and that the action may be pronounced a few days after administration of MPA.
使用健康年轻男性成年人研究了单次100毫克剂量醋酸甲羟孕酮（MPA）对人类睡眠的影响。在进行基线夜间记录后，记录了连续两个服用MPA的夜晚以及随后的两个停药夜晚。在第二个服用MPA的夜晚后总睡眠时间减少，且在第一个停药夜晚减少显著。第二个服用MPA的夜晚后睡眠中觉醒时间增加。在第二个服用MPA的夜晚和第一个停药夜晚，第1阶段睡眠显著增加。服用MPA后第4阶段睡眠减少且睡眠潜伏期逐渐增加。在第一个停药夜晚快速眼动睡眠略有减少。这些结果表明，MPA对人类睡眠有轻度唤醒作用，且该作用在服用MPA几天后可能会更明显。
