White C J, Ramee S R, Card H G, Abrahams L A, Svinarich J T, Wade C E, Rodkey W G, Virmani R
Division of Cardiology, Walter Reed Army Medical Center, Washington, DC 20307.
Lasers Surg Med. 1988;8(3):318-21. doi: 10.1002/lsm.1900080315.
Rapid production of occlusive, atherosclerotic iliac artery lesions was achieved in 25 of 27 (93%) Yucatan miniature swine, using a combination of high cholesterol diet and mechanical endothelial denudation. Animals were fed a diet with 2% of their calories as raw cholesterol 2 weeks prior to balloon denudation of iliac arteries, which resulted in atherosclerotic lesions within 8 weeks. Early after denudation we have demonstrated total occlusion of arteries by fibrin thrombi, which in time organize and ultimately result in fibrotic occlusive disease. The arterial walls and intima show varying degrees of foam cell infiltration with destruction of the internal elastic lamina and calcification. Totally occluded lesions show fibrointimal proliferation, fibrosis, and multiluminal channels, which are probably secondary to organized thrombus. Our model of occlusive iliac artery disease involving vessels of 1 to 3 mm in diameter allows the development of catheter systems suitable for use in human peripheral and coronary arteries. This model is useful for the study of angioplasty, whether mechanical, balloon, or laser-mediated.
通过高胆固醇饮食和机械性内皮剥脱相结合的方法，在27只尤卡坦小型猪中的25只（93%）身上迅速产生了闭塞性动脉粥样硬化性髂动脉病变。在对髂动脉进行球囊剥脱术前2周，给动物喂食含2%热量来源为未加工胆固醇的饮食，这导致在8周内出现动脉粥样硬化病变。剥脱术后早期，我们已证明动脉被纤维蛋白血栓完全阻塞，这些血栓会逐渐机化并最终导致纤维化闭塞性疾病。动脉壁和内膜显示出不同程度的泡沫细胞浸润，伴有内弹性膜破坏和钙化。完全闭塞的病变表现为纤维内膜增生、纤维化和多腔通道，这可能继发于机化血栓。我们的闭塞性髂动脉疾病模型涉及直径为1至3毫米的血管，可用于开发适用于人类外周和冠状动脉的导管系统。该模型对于研究血管成形术很有用，无论是机械性、球囊还是激光介导的血管成形术。
