Magi Gian Enrico, Mariotti Francesca, Berardi Sara, Piccinini Andrea, Vullo Cecilia, Palumbo Piccionello Angela, Rossi Giacomo
School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024, Matelica, MC, Italy.
Acta Vet Scand. 2018 Apr 24;60(1):25. doi: 10.1186/s13028-018-0379-3.
Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome in veterinary medicine characterized by severe intestinal dysmotility without evidence of mechanical occlusion of the intestinal lumen. The exact pathogenesis of CIPO is unknown.
A 1-year-old male Miniature Bull Terrier dog was presented with a history of chronic weight loss, regurgitation, lethargy, vomiting and diarrhea. The dog was submitted for exploratory laparotomy. A full thickness intestinal biopsy was taken and a CIPO was suspected. The clinical condition deteriorated and the dog was euthanized. At gross examination the small intestine was severely dilated. Histologically severe fibrosis of the submucosa and severe atrophy of the tunica muscularis were present in small intestine and colon. Immunohistochemical examination with a panel of antibodies for gastro-intestinal neuromuscular disease-associated antigens revealed a severely reduced expression of alpha-smooth muscle actin in the tunica muscularis.
This case report describes the gross, histological and immunohistochemical findings of CIPO affecting a 1-year-old Miniature Bull Terrier; on the basis of these findings a myopathic form of CIPO is hypothesized in this case.
慢性肠假性梗阻（CIPO）是兽医学中一种罕见的临床综合征，其特征为严重的肠道运动障碍，且无肠腔机械性梗阻的证据。CIPO的确切发病机制尚不清楚。
一只1岁雄性迷你牛头梗犬出现慢性体重减轻、反流、嗜睡、呕吐和腹泻病史。该犬接受了剖腹探查术。进行了全层肠活检，怀疑为CIPO。临床状况恶化，该犬实施安乐死。大体检查显示小肠严重扩张。组织学检查发现小肠和结肠黏膜下层严重纤维化，肌层严重萎缩。用一组针对胃肠神经肌肉疾病相关抗原的抗体进行免疫组织化学检查，结果显示肌层中α平滑肌肌动蛋白表达严重降低。
本病例报告描述了一只1岁迷你牛头梗患CIPO的大体、组织学和免疫组织化学检查结果；基于这些发现，推测该病例为肌病型CIPO。
