Schulz W
Presse Med. 1988 May 25;17(20):1027-32.
SIN-1, a new anti-anginal compound, has been the object of extensive clinical and experimental research work. It has been injected into the coronary arteries in more than 1,000 patients, enabling its effects on coronary circulation to be studied without interference from its systemic effects. Contrary to dipyridamole or calcium channel blockers, SIN-1 dilates the main epicardial coronary vessels without blood steal. The dilatation it induces is rapid and prolonged, and its intensity is at least equivalent to that of nitroglycerin, nitrites and calcium inhibitors. Its action lasts longer than that of nitroglycerin. SIN-1 enables balloon inflation to be prolonged in percutaneous transluminal coronary angioplasty. It is effective in relieving coronary spasm and has a favourable effect on anterograde and collateral circulation. Haemodynamically, SIN-1 significantly reduces preload but has little effect on afterload; it does not alter left ventricular contractility and has no influence on peripheral resistance. Owing to its rapid and long-lasting dilating effect specifically on the epicardial coronary arteries, its effectiveness against coronary spasm and its lack of side-effects, SIN-1 is indicated for coronary arteriography and coronary spasms.
新型抗心绞痛化合物SIN-1已成为广泛临床和实验研究工作的对象。它已被注射到1000多名患者的冠状动脉中，从而能够在不受其全身作用干扰的情况下研究其对冠脉循环的影响。与双嘧达莫或钙通道阻滞剂不同，SIN-1可扩张主要的心外膜冠状动脉且无窃血现象。它所引起的扩张迅速且持久，其强度至少等同于硝酸甘油、亚硝酸盐和钙抑制剂。其作用持续时间比硝酸甘油更长。SIN-1可使经皮腔内冠状动脉成形术中的球囊扩张时间延长。它对缓解冠状动脉痉挛有效，对顺行和侧支循环有有利影响。在血流动力学方面，SIN-1可显著降低前负荷，但对后负荷影响不大；它不改变左心室收缩力，对外周阻力无影响。由于其对心外膜冠状动脉具有迅速且持久的扩张作用、对冠状动脉痉挛有效且无副作用，SIN-1适用于冠状动脉造影和冠状动脉痉挛。
