Lund Lars Christian, Holzknecht Barbara Juliane, Justesen Ulrik Stenz
Ugeskr Laeger. 2018 Apr 16;180(16).
Vancomycin-resistant enterococci (VRE) are a growing healthcare concern, and since 2012 the incidence has increased eightfold in Denmark. Treatment options for infections with ampicillin-resistant VRE are sparse, and there are no Danish guidelines concerning this topic. For treatment of uncomplicated VRE urinary tract infections, ciprofloxacin or nitrofurantoin can be used. The mainstay of treatment of bacteraemia and other severe infections caused by VRE is linezolid or high-dose daptomycin. Combination treatment is recommended for complicated infections and/or prolonged therapy.
耐万古霉素肠球菌(VRE)日益引起医疗保健领域的关注,自2012年以来,丹麦的发病率增长了八倍。耐氨苄西林VRE感染的治疗选择有限,丹麦也没有关于这一主题的指南。对于单纯性VRE尿路感染的治疗,可使用环丙沙星或呋喃妥因。治疗由VRE引起的菌血症和其他严重感染的主要药物是利奈唑胺或高剂量达托霉素。对于复杂性感染和/或延长治疗,建议采用联合治疗。