Zhong Sue, Zhou Hezheng, Chen Xiao, Zhang Wenqiang, Yi Liqun
Southern Medical University, Guangzhou, 510515, Guangdong, China.
Department of Ophthalmology, Wuhan General Hospital of the People's Liberation Army, 627 S. Wu Luo Road, Wuhan, 430070, Hubei, China.
Int Ophthalmol. 2019 Apr;39(4):745-752. doi: 10.1007/s10792-018-0869-3. Epub 2018 Apr 24.
To investigate the influence of trabeculectomy and phacotrabeculectomy on the ocular surface.
Retrospective, case-control study.
Eighty-one samples without dry eyes were recruited and divided into three groups, including phacoemulsification group (N = 30) as control group, trabeculectomy group (N = 27) and phacotrabeculectomy group (N = 24) as study groups. Ocular surface parameters, including noninvasive keratograph first (NifBUT) and average (NiaBUT) tear film breakup time, tear meniscus height (TMH) and corneal fluorescein stain (CFS), were estimated preoperatively, at 3 days, 1 month and 3 months postoperatively using oculus keratograph.
No significant difference was observed in ocular surface parameters at baseline among three groups (p > 0.05). The magnitude of NifBUT and NiaBUT was reduced at 3 days and 1 month postoperatively in phacotrabeculectomy group, but greater than that in the other two groups (All p < 0.001). In all the groups, both the NifBUT and NiaBUT tended to recover at 1 and 3 months postoperatively, whereas both of them did not recover to baseline at 3 months postoperatively in trabeculectomy (NifBUT, p = 0.001; NiaBUT, p < 0.001) and phacotrabeculectomy group (NifBUT, p < 0.001; NiaBUT, p = 0.020). TMH was raised at 3 days postoperatively and restored to the baseline level at 1 and 3 months postoperatively for three groups (p > 0.05). CFS was elevated at 3 days postoperatively and different in recovery at 1 and 3 months postoperatively for three groups.
The influence of phacotrabeculectomy on ocular surface is worse than that of trabeculectomy for the short run and is not distinct different for a long time.
探讨小梁切除术和超声乳化小梁切除术对眼表的影响。
回顾性病例对照研究。
招募81例无干眼的样本，分为三组，包括作为对照组的超声乳化术组（N = 30）、小梁切除术组（N = 27）和作为研究组的超声乳化小梁切除术组（N = 24）。使用眼表分析仪术前、术后3天、1个月和3个月评估眼表参数，包括非侵入性角膜地形图首次（NifBUT）和平均（NiaBUT）泪膜破裂时间、泪河高度（TMH）和角膜荧光素染色（CFS）。
三组基线时眼表参数无显著差异（p > 0.05）。超声乳化小梁切除术组术后3天和1个月时NifBUT和NiaBUT降低，但高于其他两组（所有p < 0.001）。在所有组中，NifBUT和NiaBUT在术后1个月和3个月时均趋于恢复，而小梁切除术组（NifBUT，p = 0.001；NiaBUT，p < 0.001）和超声乳化小梁切除术组（NifBUT，p < 0.001；NiaBUT，p = 0.020）术后3个月时两者均未恢复至基线水平。三组术后3天TMH升高，术后1个月和3个月恢复至基线水平（p > 0.05）。三组术后3天CFS升高，术后1个月和3个月恢复情况不同。
短期内超声乳化小梁切除术对眼表的影响比小梁切除术更严重，长期来看两者无明显差异。
