Guo Rongjie, Jiang Jiaxuan, Zhang Yanan, Liang Qi, Liu Jiao, Hu Kai
Department of Ophthalmology, The Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Heliyon. 2023 Sep 9;9(9):e19971. doi: 10.1016/j.heliyon.2023.e19971. eCollection 2023 Sep.
To evaluate the effects of chalazion excision on the ocular surface, taking into account the subjective symptoms and the objective parameters of the tear film.
This prospective, interventional clinical study included 52 eyes from 26 patients with eyelid chalazion who underwent excision of the lesions between March and August 2022. Chalazion excision was performed on the patient's chalazion eye, and the contralateral eye served as the control. The following parameters were investigated both preoperatively and 1 week, 1 month, and 3 months postoperatively: the Ocular Surface Disease Index (OSDI), Schirmer I test, corneal fluorescein stain (CFS), tear meniscus height (TMH), noninvasive first breakup time (NifBUT), noninvasive average breakup time (NiaBUT), bulbar conjunctival redness score, the thickness of the lipid layer, and meibomian gland loss.
Before surgery, the OSDI score of the chalazion eye was significantly higher than the contralateral eye. The bulbar conjunctival redness score ( = 0.043) and the OSDI score ( = 0.004) improved significantly in the first month after surgery. In the third month after surgery, the objective parameters showed significant improvements, including TMH ( = 0.032), NiaBUT ( = 0.028), bulbar conjunctival redness score ( < 0.001), the thickness of the lipid layer ( = 0.021), and meibomian gland loss ( = 0.005).
Our study revealed that chalazion excision can significantly improve the subjective symptoms and the objective tear film parameters of the ocular surface.
考虑主观症状和泪膜客观参数，评估睑板腺囊肿切除术对眼表的影响。
这项前瞻性、干预性临床研究纳入了2022年3月至8月间接受病变切除的26例睑板腺囊肿患者的52只眼。对患者患睑板腺囊肿的眼睛进行睑板腺囊肿切除术，对侧眼作为对照。在术前以及术后1周、1个月和3个月对以下参数进行研究：眼表疾病指数（OSDI）、泪液分泌试验、角膜荧光素染色（CFS）、泪液半月高度（TMH）、非侵入性首次泪膜破裂时间（NifBUT）、非侵入性平均泪膜破裂时间（NiaBUT）、球结膜充血评分、脂质层厚度和睑板腺缺失情况。
手术前，睑板腺囊肿眼的OSDI评分显著高于对侧眼。术后第一个月，球结膜充血评分（P = 0.043）和OSDI评分（P = 0.004）有显著改善。术后第三个月，客观参数有显著改善，包括TMH（P = 0.032）、NiaBUT（P = 0.028）、球结膜充血评分（P < 0.001）、脂质层厚度（P = 0.021）和睑板腺缺失情况（P = 0.005）。
我们的研究表明，睑板腺囊肿切除术可显著改善眼表的主观症状和泪膜客观参数。
