Larsen C G, Ternowitz T, Larsen F G, Thestrup-Pedersen K
Department of Dermatology, Marselisborg Hospital, University of Aarhus, Denmark.
Arch Dermatol Res. 1988;280(2):83-8. doi: 10.1007/BF00417709.
Forty-one persons were tested for tuberculin skin reactivity. Epidermal cells (ECs) were isolated from the tuberculin reaction and from a contra lateral, non injected skin area. We found a significant increase of epidermal thymocyte activating factor (ETAF) in epidermis overlying a positive tuberculin reaction together with an increase of OKT6 and class II (HLA-DR) positive cells. Allogeneic lymphocytes proliferated significantly more when mixed with ECs from a positive tuberculin skin test. Injection of tuberculin per se or a negative reaction did not induce similar changes. The described model seems useful for functional studies of ECs and lymphocytes in patients with contact dermatitis.
对41人进行了结核菌素皮肤反应性检测。从结核菌素反应部位及对侧未注射皮肤区域分离出表皮细胞（ECs）。我们发现，在结核菌素反应阳性部位的表皮中，表皮胸腺细胞活化因子（ETAF）显著增加，同时OKT6和II类（HLA - DR）阳性细胞也增加。当与结核菌素皮肤试验阳性的ECs混合时，同种异体淋巴细胞的增殖明显更多。注射结核菌素本身或阴性反应并未诱导类似变化。所描述的模型似乎对接触性皮炎患者的ECs和淋巴细胞功能研究有用。
