Cheung D W
Department of Pharmacology, University of Toronto, Ontario, Canada.
Biochem Biophys Res Commun. 1988 Jul 15;154(1):411-6. doi: 10.1016/0006-291x(88)90701-2.
The effect of atriopeptin III (AP III) on the excitability of the inferior mesenteric ganglion (IMG) of the guinea-pig was studied by intracellular recording technique. AP III depressed the excitability of the IMG by decreasing the frequency of the action potentials, prolonging the afterpotential and increasing the threshold of the action potentials. Voltage-clamp studies revealed that a transient potassium current-the A current-was enhanced by AP III. It is suggested that inhibition of the sympathetic nervous system may contribute to the cardiovascular effect of AP III.
采用细胞内记录技术研究了心房肽III（AP III）对豚鼠肠系膜下神经节（IMG）兴奋性的影响。AP III通过降低动作电位频率、延长后电位和提高动作电位阈值来降低IMG的兴奋性。电压钳研究表明，AP III增强了一种瞬时钾电流——A电流。提示交感神经系统的抑制可能是AP III心血管效应的原因之一。
