Han Bing, Li Qin, Wang Ningjian, Chen Yi, Zhu Chunfang, Chen Yingchao, Xia Fangzhen, Cang Zhen, Lu Meng, Meng Ying, Chen Chi, Lu Yingli
Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Int J Endocrinol. 2018 Mar 6;2018:1216370. doi: 10.1155/2018/1216370. eCollection 2018.
The relationship between vitamin D and insulin resistance is still controversial. Many factors could influence this relationship. In addition, this relationship in different genders was still unclear.
A total of 6597 subjects, including 2813 males and 3784 females, were analyzed. The serum levels of 25(OH)D, fasting blood glucose (FBG), fasting insulin, HbA1c, and other metabolic parameters were tested. The waist circumference (WC), weight, and height were also measured. Questionnaires regarding smoking and drinking were collected from these subjects.
Serum 25(OH)D was categorized into quartiles. Increasing 25(OH)D levels were associated with reduced trend of homeostasis model assessment of insulin resistance (HOMA-IR) in both males and females. Pearson's correlation indicated 25(OH)D level was inversely associated with the HOMA-IR for male subjects ( = -0.055, = 0.028) but not for female subjects ( = -0.005, = 0.798). Age, triglyceride (TG), and low-density lipoprotein (LDL) were associated with the vitamin D levels in males and females. In regression analysis, serum 25(OH)D concentration was significantly associated with HOMA-IR only in overweight males.
We found an inverse association between 25(OH)D and HOMA-IR in Chinese overweight males. Vitamin D supplementation might be beneficial in this population. However, further clinical trials are needed to confirm this association.
维生素D与胰岛素抵抗之间的关系仍存在争议。许多因素可能影响这种关系。此外，这种关系在不同性别中的情况仍不清楚。
共分析了6597名受试者，其中男性2813名，女性3784名。检测了血清25(OH)D、空腹血糖(FBG)、空腹胰岛素、糖化血红蛋白(HbA1c)及其他代谢参数。还测量了腰围(WC)、体重和身高。收集了这些受试者关于吸烟和饮酒的问卷。
血清25(OH)D被分为四分位数。25(OH)D水平升高与男性和女性胰岛素抵抗稳态模型评估(HOMA-IR)的下降趋势相关。Pearson相关性分析表明，25(OH)D水平与男性受试者的HOMA-IR呈负相关(r = -0.055，P = 0.028)，而与女性受试者无关(r = -0.005，P = 0.798)。年龄、甘油三酯(TG)和低密度脂蛋白(LDL)与男性和女性的维生素D水平相关。在回归分析中，血清25(OH)D浓度仅在超重男性中与HOMA-IR显著相关。
我们发现中国超重男性中25(OH)D与HOMA-IR之间存在负相关。补充维生素D可能对该人群有益。然而，需要进一步的临床试验来证实这种关联。
