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从红淡比(Corylopsis coreana Uyeki)中分离得到的酚类化合物对人前列腺癌细胞系的抗氧化和抗增殖活性。

Anti-oxidative and anti-proliferative activity on human prostate cancer cells lines of the phenolic compounds from Corylopsis coreana Uyeki.

机构信息

College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.

出版信息

Molecules. 2013 Apr 24;18(5):4876-86. doi: 10.3390/molecules18054876.

DOI:10.3390/molecules18054876
PMID:23615534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6270069/
Abstract

Fifteen phenolic compounds, including three caffeoyl derivatives, four gallotannins, three ellagitannins and five flavonoids, were isolated from an 80% MeOH extract of the leaves of Corylopsis coreana Uyeki (Korean winter hazel; CL). The anti-oxidative activities [1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and xanthine oxidase superoxide scavenging activities (NBT)] and the anti-proliferative activity on human prostate cancer cell lines (DU145 and LNCaP) were also evaluated.

摘要

从朝鲜毛核木(Corylopsis coreana Uyeki;CL)叶的 80%甲醇提取物中分离得到了 15 种酚类化合物,包括 3 种咖啡酰衍生物、4 种没食子鞣质、3 种鞣花单宁和 5 种类黄酮。还评估了它们的抗氧化活性[1,1-二苯基-2-苦基肼(DPPH)自由基清除活性和黄嘌呤氧化酶超氧阴离子清除活性(NBT)]以及对人前列腺癌细胞系(DU145 和 LNCaP)的增殖抑制活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d2/6270069/2760099a632d/molecules-18-04876-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d2/6270069/c218fa72c66d/molecules-18-04876-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d2/6270069/d063050e68bc/molecules-18-04876-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d2/6270069/2760099a632d/molecules-18-04876-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d2/6270069/c218fa72c66d/molecules-18-04876-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d2/6270069/d063050e68bc/molecules-18-04876-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4d2/6270069/2760099a632d/molecules-18-04876-g002.jpg

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