Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
Biomed Res Int. 2018 Mar 5;2018:6486407. doi: 10.1155/2018/6486407. eCollection 2018.
Cesarean scar pregnancy (CSP) is a rare condition that occurs when the pregnancy implants in a cesarean scar. An early diagnosis and a proper management are fundamental to prevent maternal complications. We review and discuss the different treatment employed in our unit to reduce morbidity, preserve fertility, and predict possible complications.
The reported treatment has been expectant management, operative hysteroscopy approach, and intramuscular injection of 50 mg methotrexate (MTX), followed by cervical dilation and manual vacuum aspiration (D&S) with a Karman cannula under ultrasound guidance, uterine artery embolization (UAE), and manual vacuum aspiration under ultrasound guidance and uterine artery embolization before surgical laparotomic resection.
Complications were more frequent in women with a history of three or more cesarean section deliveries and with a myometrial thickness thinner than 2 mm. MTX and D&S treatment appear to be most effective and safe at the early age of pregnancy, while UAE and D&S are related to the highest risk of complication in any age of pregnancy.
An appropriate preoperative diagnostic evaluation, the identification of cases at higher risk, and those eligible for a conservative treatment are fundamental to reduce complications.
剖宫产瘢痕妊娠(CSP)是一种罕见的疾病,当妊娠着床于剖宫产瘢痕处时发生。早期诊断和适当的处理对于预防母体并发症至关重要。我们回顾并讨论了我们科室采用的不同治疗方法,以降低发病率、保留生育能力并预测可能出现的并发症。
报道的治疗方法包括期待治疗、手术宫腔镜方法、肌内注射 50mg 甲氨蝶呤(MTX),随后在超声引导下行宫颈扩张和手动真空抽吸(D&S)联合 Karman 套管,子宫动脉栓塞术(UAE),以及超声引导下手动真空抽吸和手术剖腹切除前的子宫动脉栓塞术。
有 3 次或更多剖宫产史和肌层厚度小于 2mm 的女性并发症更为常见。在妊娠早期,MTX 和 D&S 治疗似乎最有效且安全,而在任何妊娠年龄,UAE 和 D&S 与最高的并发症风险相关。
适当的术前诊断评估、识别高风险病例和适合保守治疗的病例是降低并发症的关键。