GEMMs Are a Gem When it Comes to Defining the Role of HIF2α in Mucinous Cystic Neoplasms.
作者信息
Boyle Kathleen A, Dwinell Michael B
机构信息
Department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin.
出版信息
Cell Mol Gastroenterol Hepatol. 2017 Dec 8;5(2):165-166. doi: 10.1016/j.jcmgh.2017.11.008. eCollection 2018.
Abstract
摘要
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本文引用的文献
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Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm.胰腺缺氧诱导因子2α（HIF2α）的稳定导致慢性胰腺炎并易患黏液性囊性肿瘤。
Cell Mol Gastroenterol Hepatol. 2017 Nov 10;5(2):169-185.e2. doi: 10.1016/j.jcmgh.2017.10.008. eCollection 2018.
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In vivo functional dissection of a context-dependent role for Hif1α in pancreatic tumorigenesis.Hif1α在胰腺肿瘤发生中依赖于环境的作用的体内功能剖析。
Oncogenesis. 2016 Dec 12;5(12):e278. doi: 10.1038/oncsis.2016.78.
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HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer.缺氧诱导因子-2α通过调控Twist2与胰腺癌中E-钙黏蛋白启动子的结合来促进上皮-间质转化。
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Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia.Hif1a缺失揭示了B细胞在胰腺肿瘤形成中的促肿瘤功能。
Cancer Discov. 2016 Mar;6(3):256-69. doi: 10.1158/2159-8290.CD-15-0822. Epub 2015 Dec 29.
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PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis.HIF2α 在早期胰腺肿瘤发生过程中对 PanIN 特异性的 Wnt 信号的调节。
Cancer Res. 2013 Aug 1;73(15):4781-90. doi: 10.1158/0008-5472.CAN-13-0566. Epub 2013 Jun 7.
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Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma.Notch2 对于胰腺上皮内瘤变的进展和胰腺导管腺癌的发生是必需的。
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13438-43. doi: 10.1073/pnas.1002423107. Epub 2010 Jul 12.
7
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.Kras（G12D）和Smad4/Dpc4单倍体不足协同作用，诱导胰腺黏液性囊性肿瘤和浸润性腺癌。
Cancer Cell. 2007 Mar;11(3):229-43. doi: 10.1016/j.ccr.2007.01.017.
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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.Trp53R172H和KrasG12D共同作用，促进小鼠染色体不稳定和广泛转移的胰腺导管腺癌。
Cancer Cell. 2005 May;7(5):469-83. doi: 10.1016/j.ccr.2005.04.023.
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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.小鼠胰腺导管原位癌和浸润性癌及其早期检测
Cancer Cell. 2003 Dec;4(6):437-50. doi: 10.1016/s1535-6108(03)00309-x.
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