State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.
Chem Commun (Camb). 2018 May 10;54(39):4927-4930. doi: 10.1039/c8cc01774c.
A cobalt-catalyzed oxidative coupling of benzoic hydrazides with maleimides by utilizing 2-(1-methylhydrazinyl)pyridine as a bidentate directing group has been developed. This C-H functionalization/spirocyclization cascade protocol shows high efficiency and remarkable functional group tolerance, and the ubiquitous spirosuccinimides were obtained in good to excellent yields with high regioselectivity. This strategy also provides a novel and efficient access to diverse symmetric and unsymmetrical bisspirosuccinimides.
发展了一种钴催化的苯甲酰基腙与马来酰亚胺的氧化偶联反应，利用 2-(1-甲基肼基)吡啶作为双齿导向基团。这种 C-H 功能化/螺环化级联反应具有高效和显著的官能团容忍性，广泛存在的螺琥珀酰亚胺以良好到优异的收率和高区域选择性得到。该策略还为各种对称和不对称的双螺琥珀酰亚胺提供了一种新的有效方法。
