Dental Research Center, Department of Oral & Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Oral & Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Int J Dermatol. 2018 Jul;57(7):794-798. doi: 10.1111/ijd.14007. Epub 2018 Apr 24.
Dysfunction of adhesion molecules is believed to play an early and important role in developing cancer. Accordingly, this study aims to compare beta-catenin (β-catenin) and CD44 expression in oral lichen planus (OLP) as a condition with malignant potential and oral squamous cell carcinoma (OSCC).
β-Catenin and CD44 expression were evaluated in 15 patients with epithelial hyperplasia (group A), 20 OLP (group B), and 20 OSCC (group C) by immunohistochemistry.
Quantitative and semi-quantitative evaluations revealed β-catenin, and CD44 membranous expression had significant differences among the three groups. Expression of these markers in the OSCC group decreased significantly compared to that of the OLP. Also, nuclear/cytoplasmic expression of β-catenin was significantly different among the three groups, considering that nuclear expression was not observed in any of the epithelial hyperplasia and OLP samples.
According to the findings of this study, β-catenin and CD44 can differentiate between behavior of OLP and OSCC, while the precancerous nature of OLP and malignant transformation potential of it are not suggested.
黏附分子功能障碍被认为在癌症发展的早期起着重要作用。因此，本研究旨在比较具有恶性潜能的口腔扁平苔藓（OLP）和口腔鳞状细胞癌（OSCC）中β-连环蛋白（β-catenin）和 CD44 的表达。
采用免疫组织化学法检测 15 例上皮增生患者（A 组）、20 例 OLP（B 组）和 20 例 OSCC（C 组）中β-catenin 和 CD44 的表达。
定量和半定量评估显示，三组之间β-catenin 和 CD44 的膜表达有显著差异。与 OLP 相比，OSCC 组这些标志物的表达显著降低。此外，β-catenin 的核/质表达在三组之间也有显著差异，因为上皮增生和 OLP 样本中均未观察到核表达。
根据本研究的结果，β-catenin 和 CD44 可以区分 OLP 和 OSCC 的行为，而不能提示 OLP 的癌前性质和恶性转化潜能。
