Korevaar Tim I M, Tiemeier Henning, Peeters Robin P
Rotterdam Thyroid Center, Erasmus Medical Center, Rotterdam, The Netherlands.
Child and Adolescent Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands.
Clin Endocrinol (Oxf). 2018 Aug;89(2):129-138. doi: 10.1111/cen.13724. Epub 2018 May 16.
Thyroid hormone is an important regulator of early brain development, particularly during early stages of gestation during which foetal thyroid hormone availability depends on the maternal transfer of thyroid hormones. There is a wide range of experimental studies showing that low maternal thyroid hormone availability is associated with suboptimal brain development parameters. While few clinical studies have shown that overt maternal hypothyroidism is associated with lower child IQ, the question whether more subclinical changes in maternal thyroid function could also lead to suboptimal foetal brain development. In this review, we put the latter studies in perspective and discuss their interpretation from an epidemiological and clinical perspective. Furthermore, we extend this discussion to also include future perspective and identify important knowledge gaps in the field.
甲状腺激素是早期大脑发育的重要调节因子，尤其是在妊娠早期，此时胎儿甲状腺激素的供应依赖于母体甲状腺激素的传递。大量实验研究表明，母体甲状腺激素供应不足与大脑发育参数不理想有关。虽然很少有临床研究表明显性母体甲状腺功能减退与儿童智商较低有关，但母体甲状腺功能更细微的变化是否也会导致胎儿大脑发育不理想仍是个问题。在这篇综述中，我们对后者的研究进行了审视，并从流行病学和临床角度讨论了对它们的解读。此外，我们还将这一讨论扩展到未来展望，并指出该领域的重要知识空白。
