Mustonen Allison, Gonzalez Olga, Mendoza Elda, Kumar Shyamesh, Dick Edward J
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
J Med Primatol. 2018 Apr 25. doi: 10.1111/jmp.12348.
Uremic encephalopathy is uncommon yet is one of the most severe complications of renal failure. We present a case of acute renal failure and associated cerebral and vascular lesions consistent with uremic encephalopathy in a rhesus macaque (Macaca mulatta).
A 14-year-old, female, specific-pathogen-free rhesus macaque presented in lateral recumbency, obtunded, severely dehydrated, and hypothermic, with severe azotemia, mild hyponatremia, hypokalemia, hypochloremia, increased anion gap, and hypercholesterolemia. Due to poor prognosis, the animal was euthanized and a complete necropsy was conducted.
The animal had diffuse proximal renal tubular epithelial necrosis and loss; regeneration of tubular epithelium was not observed. There was bilateral necrosis and loss of neurons and glial cells in the hippocampus and deep cerebral cortex with edema and multifocal areas of hemorrhage.
We present the first reported case of uremic encephalopathy in a rhesus macaque and describe the associated cerebral and vascular lesions.
尿毒症性脑病并不常见，但却是肾衰竭最严重的并发症之一。我们报告了一例恒河猴（猕猴属）出现急性肾衰竭并伴有符合尿毒症性脑病的脑和血管病变。
一只14岁的雌性无特定病原体恒河猴侧卧，意识迟钝，严重脱水且体温过低，伴有严重氮质血症、轻度低钠血症、低钾血症、低氯血症、阴离子间隙增加和高胆固醇血症。由于预后不良，对该动物实施安乐死并进行了完整的尸检。
该动物出现弥漫性近端肾小管上皮坏死和脱落；未观察到肾小管上皮再生。海马体和大脑深层皮质存在双侧神经元和神经胶质细胞坏死及脱落，并伴有水肿和多灶性出血区域。
我们报告了首例恒河猴尿毒症性脑病病例，并描述了相关的脑和血管病变。
