血清CXCL12而非CXCR4与头颈部鳞状细胞癌相关。
Serum CXCL12, but not CXCR4, Is Associated with Head and Neck Squamous Cell Carcinomas.
作者信息
Lavaee Fatemeh, Zare Sahar, Mojtahedi Zahra, Malekzadeh Mahyar, Khademi Bijan, Ghaderi Abbas
机构信息
Oral and Dental Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Email:
出版信息
Asian Pac J Cancer Prev. 2018 Apr 25;19(4):901-904. doi: 10.22034/APJCP.2018.19.4.901.
Background: Squamous cell carcinoma (SCC) is the most frequent malignancy of the head and neck (HN) region. We here evaluated associations of stromal cell derived factor-1 (SDF-1or CXCL12) and its receptor, CXCR4, with HNSCCs. Materials and Methods: Sixty newly diagnosed HNSCC patients were enrolled in the patient group, and 28 healthy individuals in the control group. Plasma levels of CXCL12 and CXCR4 were measured using ELISA kits. Results: There was a significant difference in mean CXCL12, but not CXCR4, plasma levels between the patient and control groups (P=0.0001). No significant associations were found between mean plasma levels of either CXCL12 or CXCR4 with age, gender, tumor site, tumor size, lymph-node involvement or tumor stage. Conclusion: For the first time, our findings demonstrate a significant association between serum CXCL12 but not CXCR4 levels and HNSCCs.
背景
鳞状细胞癌（SCC）是头颈部（HN）区域最常见的恶性肿瘤。我们在此评估基质细胞衍生因子-1（SDF-1 或 CXCL12）及其受体 CXCR4 与头颈部鳞状细胞癌（HNSCC）的相关性。材料与方法：患者组纳入 60 例新诊断的 HNSCC 患者，对照组纳入 28 名健康个体。使用 ELISA 试剂盒检测血浆中 CXCL12 和 CXCR4 的水平。结果：患者组和对照组之间血浆 CXCL12 的平均水平存在显著差异，但 CXCR4 无显著差异（P = 0.0001）。CXCL12 或 CXCR4 的平均血浆水平与年龄、性别、肿瘤部位、肿瘤大小、淋巴结受累情况或肿瘤分期之间未发现显著相关性。结论：我们的研究结果首次证明血清 CXCL12 水平而非 CXCR4 水平与 HNSCC 之间存在显著关联。
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