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[快速眼动睡眠剥夺后大鼠大脑神经元和神经胶质细胞中的ATP酶活性(细胞光度学研究)]

[ATPase activity in neurons and glial cells of the brain of the rat after REM-sleep deprivation (cytophotometric study)].

作者信息

Klenikova V A, Taranova N P

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1988 Apr;74(4):490-6.

PMID:2969342
Abstract

Modified Washstein and Meisel's techniques were used for quantitative estimation of ATPases activity in the rat brain. The specific activity of Na+,K+-ATPase and Mg2+-ATPase was higher in glial cells than in the neurons. The 24-hr REM-sleep deprivation resulted in an enhancement of the activity of ATPases in neurons of the hippocampus whereas the activity of the above enzymes lowered in the gliocytes. The findings can be due to the changes in excitability of the neurons and depolarization of glia during the sleep deprivation.

摘要

采用改良的沃施泰因和迈泽尔技术对大鼠脑中的ATP酶活性进行定量估计。胶质细胞中Na + 、K + -ATP酶和Mg2 + -ATP酶的比活性高于神经元。24小时快速眼动睡眠剥夺导致海马体神经元中ATP酶活性增强,而上述酶在神经胶质细胞中的活性降低。这些发现可能是由于睡眠剥夺期间神经元兴奋性的变化和神经胶质细胞的去极化所致。

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