Neuroscience and Psychiatry Unit,Division of Neuroscience and Experimental Psychology,University of Manchester and Manchester Academic Health Science Centre,Manchester M13 9PT,UK.
Br J Psychiatry. 2018 May;212(5):259-261. doi: 10.1192/bjp.2018.56.
Although in common use, treatment-resistant depression is unhelpful both conceptually and practically. In this issue a new term, multiple-therapy-resistant major depressive disorder, is proposed; although it may be useful in guiding treatment options for patients with persisting depression, it should not be an automatic trigger for further, more invasive treatments.Declaration of interestsI.M.A. has been a consultant for pharmaceutical companies developing and marketing antidepressants and has been an author on publications that have used the term treatment-resistant depression.
虽然在临床上普遍使用，但“治疗抵抗性抑郁症”这个术语无论在概念上还是在实践上都没有帮助。本期提出了一个新术语，即“多种疗法抵抗性重度抑郁症”；虽然它可能有助于指导持续性抑郁症患者的治疗选择，但不应成为进一步更具侵入性治疗的自动触发因素。利益声明 I.M.A. 曾为开发和销售抗抑郁药的制药公司担任顾问，并曾参与使用“治疗抵抗性抑郁症”这一术语的出版物的撰写。
