de Figueiredo E Silva Rama A L, de Gois Speck N M, Nogueira de Carvalho C R, Schimidt M A, Ribalta J C Lascasas
Eur J Gynaecol Oncol. 2017;38(3):368-371.
To compare the use of topical 5% imiquimodt (IMQ) cream or CO2 laser vaponization as the treatment of vulvar inmraepithelial lesions (VIN) 2/3 and to evaluate the degrees of residual or recurrent lesions.
Twenty-nine women with VIN 2/3 were separated into two groups, according to the proposed treatments. All were submitted to collection of vulvar swabs for DNA genotyping of human papillomavirus (HPV), vulvoscopy, and biopsy of the found lesions. After treatment they were followed up in quarterly consultations to (until) possible appearance of new lesions or along one year.
The findings were similar in effectiveness and presence of residual or recurrent lesions on the performed treatments. However, patients treated with topical 5% IMQ cream had less severe lesions in histological recurrence when compared to those submitted to the CO2 laser vaporization.
The effectiveness of topical 5% IMQ cream was similar to that of CO2 laser vaporization. There was no difference between the treatments for the presence of residual or recurrent lesions. However, patients who received IMQ had less aggressive lesions than those submitted to the treatment with CO2 laser vaporization.
比较外用5%咪喹莫特（IMQ）乳膏与二氧化碳激光汽化术治疗外阴上皮内瘤变（VIN）2/3的效果，并评估残留或复发病变的程度。
29例VIN 2/3患者根据拟定治疗方法分为两组。所有患者均采集外阴拭子进行人乳头瘤病毒（HPV）DNA基因分型、外阴镜检查及对发现的病变进行活检。治疗后每季度复诊随访（直至）可能出现新病变或随访一年。
所实施治疗在有效性以及残留或复发病变方面的结果相似。然而，与接受二氧化碳激光汽化术的患者相比，外用5% IMQ乳膏治疗的患者组织学复发时病变程度较轻。
外用5% IMQ乳膏的有效性与二氧化碳激光汽化术相似。在残留或复发病变方面，两种治疗方法无差异。然而，接受IMQ治疗的患者病变侵袭性低于接受二氧化碳激光汽化术治疗者。
