Zhang Ruina, Wang Li
Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
J Int Med Res. 2019 Aug;47(8):4019-4026. doi: 10.1177/0300060519862940. Epub 2019 Jul 31.
Vulvar intraepithelial neoplasia (VIN) is a pre-malignant condition of the vulvar skin that is found in 50% to 70% of patients with vulvar squamous cell cancer and is regarded as a precursor of vulvar tumors. Thus far, treatment remains lesion- and patient-specific. Here, we describe a VIN patient who presented with a 15-month history of large lesions in the bilateral labium, associated with human papillomavirus infection. The lesions were inappropriate for surgical excision and laser ablation because of their size; therefore, they were treated with photodynamic therapy and concurrent topical 5-aminolevulinic acid hydrochloride. The patient showed no recurrence throughout 2 years of post-treatment follow-up, and reported only slight pain during treatment. Moreover, no significant side effects or scarring were detected. Thus, we conclude that photodynamic therapy can be a useful alternative treatment for large VIN in the bilateral labium that cannot be excised or ablated.
外阴上皮内瘤变（VIN）是一种外阴皮肤的癌前病变，在50%至70%的外阴鳞状细胞癌患者中被发现，并被视为外阴肿瘤的前驱病变。迄今为止，治疗仍需根据病变情况和患者个体差异而定。在此，我们描述了一名VIN患者，其双侧阴唇出现大的病变已有15个月病史，伴有人乳头瘤病毒感染。由于病变大小，这些病变不适合手术切除和激光消融；因此，对其采用光动力疗法并同时局部应用盐酸5-氨基酮戊酸进行治疗。在治疗后的2年随访中，患者未出现复发，且仅报告在治疗期间有轻微疼痛。此外，未检测到明显的副作用或瘢痕形成。因此，我们得出结论，光动力疗法对于双侧阴唇无法切除或消融的大型VIN可能是一种有用的替代治疗方法。
