State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.
Nanoscale. 2018 Jul 9;10(26):12356-12363. doi: 10.1039/c8nr00446c.
Multimodality imaging-guided therapy based on lanthanide-doped upconversion nanoparticles (UCNPs) has become a trend in cancer theranostics. However, the overheating effect of 980 nm excitation in photodynamic therapy (PDT) and the difficulties in optimizing multimodality imaging integration within a single particle are still challenges. Herein, 800 nm driven NaErF4@NaLuF4 UCNPs have been explored for optimized multimodality imaging and near-infrared (NIR) triggered PDT. Our results confirmed that the optimal ∼5 nm shell thickness can well balance the enhancement of upconversion luminescence and the attenuation of energy transfer efficiency from Er3+ towards a photosensitizer, to achieve efficient production of singlet oxygen (1O2) for PDT under 800 nm excitation. Furthermore, the as-obtained NaErF4@NaLuF4 UCNPs showed effective and applicable performance for upconversion luminescence (UCL) imaging, X-ray computed tomography (CT), and high-field T2 magnetic resonance imaging (MRI). This nanomaterial can serve as an excellent theranostic agent for multimodality imaging and image-guided therapy.
基于镧系掺杂上转换纳米粒子（UCNPs）的多模态影像引导治疗已经成为癌症诊治的一种趋势。然而，在光动力疗法（PDT）中，980nm 激发的过热效应以及在单个粒子内优化多模态影像整合的困难仍然是挑战。在此，我们探索了 800nm 驱动的 NaErF4@NaLuF4 UCNPs，以实现优化的多模态影像和近红外（NIR）触发的 PDT。我们的结果证实，最佳的约 5nm 壳层厚度可以很好地平衡上转换发光的增强和从 Er3+向光敏剂的能量转移效率的衰减，从而在 800nm 激发下实现 PDT 中 1O2 的高效产生。此外，所获得的 NaErF4@NaLuF4 UCNPs 在上转换发光（UCL）成像、X 射线计算机断层扫描（CT）和高磁场 T2 磁共振成像（MRI）方面表现出有效的、可应用的性能。这种纳米材料可以作为一种用于多模态影像和影像引导治疗的优秀治疗剂。
