Liu Jun, Huang Long, Tian Xiumei, Chen Xiaoming, Shao Yuanzhi, Xie Fukang, Chen Dihu, Li Li
School of Electronics and Information Technology and School of Physics.
State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center; Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University.
Int J Nanomedicine. 2016 Dec 16;12:1-14. doi: 10.2147/IJN.S118938. eCollection 2017.
The development of upconversion nanoparticles (UCNs) for theranostics application is a new strategy toward the accurate diagnosis and efficient treatment of cancer. Here, magnetic and fluorescent lanthanide-doped gadolinium oxide (GdO) UCNs with bright upconversion luminescence (UCL) and high longitudinal relaxivity () are used for simultaneous magnetic resonance imaging (MRI)/UCL dual-modal imaging and photodynamic therapy (PDT). In vitro and in vivo MRI studies show that these products can serve as good MRI contrast agents. The bright upconversion luminescence of the products allows their use as fluorescence nanoprobes for live cells imaging. We also utilized the luminescence-emission capability of the UCNs for the activation of a photosensitizer to achieve significant PDT results. To the best of our knowledge, this study is the first use of lanthanide-doped GdO UCNs in a theranostics application. This investigation provides a useful platform for the development of GdO-based UCNs for clinical diagnosis, treatment, and imaging-guided therapy of cancer.
用于诊疗应用的上转换纳米粒子（UCNs）的开发是一种针对癌症精准诊断和高效治疗的新策略。在此，具有明亮上转换发光（UCL）和高纵向弛豫率（）的磁性和荧光镧系掺杂氧化钆（GdO）UCNs被用于同时进行磁共振成像（MRI）/UCL双模态成像和光动力疗法（PDT）。体外和体内MRI研究表明，这些产品可作为良好的MRI造影剂。产品明亮的上转换发光使其能够用作活细胞成像的荧光纳米探针。我们还利用UCNs的发光能力来激活光敏剂，以实现显著的PDT效果。据我们所知，本研究是首次将镧系掺杂GdO UCNs用于诊疗应用。该研究为开发基于GdO的UCNs用于癌症的临床诊断、治疗和成像引导治疗提供了一个有用的平台。
