The Mallat Family Laboratory of Organic Chemistry, Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, 3200009, Israel.
Chemistry. 2018 Jun 18;24(34):8553-8557. doi: 10.1002/chem.201802016. Epub 2018 May 22.
The distant functionalization of ω-ene cyclopropanols is induced by a Pd-catalyzed Heck reaction triggering a "metal-walk" and selective ring-opening of the three-membered ring. This approach provides a new class of acyclic aldehydes possessing concomitantly a stereodefined double bond and a quaternary carbon stereocenter α to the carbonyl group.
钯催化 Heck 反应诱导 ω-烯环丙醇的远程官能化，引发“金属行走”和三元环的选择性开环。该方法提供了一类新的非环醛，它们同时具有立体确定的双键和羰基α位的季碳立体中心。
