Pelham J M, Meyer B F, Herrmann R P, Davis R E, Raphael C L, Kraft N, Atkins R C
Haematology Department, Royal Perth Hospital.
Pathology. 1987 Apr;19(2):124-30. doi: 10.3109/00313028709077122.
The monoclonal antibody PHM-6, which is specific for the common acute lymphoblastic leukemia antigen (CALLA), was conjugated to the plant toxin ricin. Binding of the PHM-6-ricin conjugate to cells via the ricin molecule was blocked by the presence of 100 mM lactose. The IC50 (concentration resulting in 50% inhibition) of the PHM-6-ricin conjugate for the CALLA-positive KM-3 cell line was 280-fold greater than for bone marrow stem cells, indicating the potential of this conjugate for immunological purging of autologous remission marrow.
