University of California, Los Angeles Mattel Children's Hospital, Los Angeles, California
Pediatrics. 2018 May;141(5). doi: 10.1542/peds.2017-3286.
Copper deficiency is an uncommon cause of hematologic abnormalities in children that is often overlooked or misdiagnosed. Although cases have been reported because of malabsorption syndromes or after gastrointestinal surgeries, we report a case of copper deficiency-associated anemia and neutropenia in a child because of dietary restrictions, specifically, transitioning from a formula-based ketogenic diet to a pureed food-based ketogenic diet. On copper supplementation, the patient's anemia and neutropenia resolved. To our knowledge, this report is the first revealing copper deficiency anemia and neutropenia developing because of a ketogenic diet.
铜缺乏症是儿童血液系统异常的一种罕见病因，常被忽视或误诊。虽然有因吸收不良综合征或胃肠手术后导致的病例报告，但我们报告了一例因饮食限制（具体来说，从基于配方的生酮饮食过渡到基于泥状食物的生酮饮食）导致铜缺乏相关贫血和中性粒细胞减少症的儿童铜缺乏症病例。在补充铜后，患者的贫血和中性粒细胞减少症得到了缓解。据我们所知，本报告首次揭示了因生酮饮食导致的铜缺乏性贫血和中性粒细胞减少症。
