Liu Qi, Kong Fanmin, Zhou Jianping, Dong Ming, Dong Qi
Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, China.
Department of General Surgery, The People's Hospital, China Medical University, Shenyang, China.
Cancer Manag Res. 2018 Apr 12;10:735-743. doi: 10.2147/CMAR.S159689. eCollection 2018.
Gastrointestinal stromal tumors (GISTs) are relatively common mesenchymal tumors. They originate from the wall of hollow viscera and may be found in any part of the digestive tract. The prognosis of patients with stromal tumors depends on various risk factors, including size, location, presence of mitotic figures, and tumor rupture. Emergency surgery is often required for stromal tumors with hemorrhage. The current literature suggests that stromal tumor hemorrhage indicates poor prognosis. Although the optimal treatment options for hemorrhagic GISTs are based on surgical experience, there remains controversy with regard to optimum postoperative management as well as the classification of malignant potential. This article reviews the biological characteristics, diagnostic features, prognostic factors, treatment, and postoperative management of GISTs with hemorrhage.
胃肠道间质瘤（GISTs）是相对常见的间叶组织肿瘤。它们起源于中空脏器壁，可出现在消化道的任何部位。间质瘤患者的预后取决于多种风险因素，包括大小、位置、有丝分裂象的存在以及肿瘤破裂情况。伴有出血的间质瘤通常需要急诊手术。目前的文献表明，间质瘤出血提示预后不良。尽管出血性GISTs的最佳治疗方案基于手术经验，但在术后最佳管理以及恶性潜能分类方面仍存在争议。本文综述了伴有出血的GISTs的生物学特征、诊断特点、预后因素、治疗及术后管理。
