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[Proteinase participation in chromosome radiation damage. Research on the action of phenylmethylsulfonyl fluoride].

作者信息

Aptikaeva G F, Rozanova O M, Saugabaeva K M, Ganassi E E

出版信息

Radiobiologiia. 1988 May-Jun;28(3):297-302.

PMID:2969597
Abstract

Phenylmethylsulfonyl fluoride, a chromatin proteinase inhibitor, caused a nearly twofold diminution of the cytogenetic injury and a twofold increase in the rate of DNA repair in gamma-irradiated (3-15 Gy) Chinese hamster fibroblasts. The effect of the inhibitor was mainly exhibited by a rapidly repaired (for 15-20 min) component of the cytogenetic damage. A simultaneous treatment with phenylmethylsulfonyl fluoride and nicotinamide did not influence the effect of the proteinase inhibitor under study. The results obtained are indicative of poly (ADP-ribosylation)-independent contribution of chromatin proteinases to radiation-induced chromosome mutagenesis.

摘要

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