Ostrovskaia L B, Bezlepkin V G, Gaziev A I
Radiobiologiia. 1988 Sep-Oct;28(5):601-6.
A study was made of the influence of protease activity inhibition by phenylmethylsulfonyl fluoride and modification of the chromatin structure by polyamines on the rate of formation and repair of DNA single-strand breaks in 3T3 cells affected by UV- or gamma-radiation. The results obtained suggest that a change in the chromatin structure, with the participation of the proteolytic activity, may be a stage preceding endonuclease incision in the process of excision DNA repair.
研究了苯甲基磺酰氟抑制蛋白酶活性以及多胺修饰染色质结构对受紫外线或γ辐射影响的3T3细胞中DNA单链断裂形成和修复速率的影响。所得结果表明，在蛋白水解活性参与下染色质结构的变化可能是切除DNA修复过程中内切核酸酶切割之前的一个阶段。
