Haddad Fady G, El Bitar Sandy, Al Moussawi Hassan, Chang Qing, Deeb Liliane
Department of Gastroenterology and Hepatology, Staten Island University Hospital, New York.
Department of Medicine, Staten Island University Hospital/northwell Health, New York.
Cureus. 2018 Feb 24;10(2):e2224. doi: 10.7759/cureus.2224.
Diverticular disease (DD) is a leading cause of hospitalizations in developed countries affecting 30-50% of individuals older than 60 years. Identified as a distinct entity since 1980, diverticular disease-associated colitis (DAC) describes the occurrence of mucosal inflammation in a colon segment affected with DD with relative sparing of the rectum and proximal colon. Its prevalence is suggested around 1.3-3.8%. Pathogenesis is multifactorial with multiple reports noting clinicopathological overlap between DAC and inflammatory bowel disease (IBD) especially in patients with granulomatous colitis. In this setting, caution should be exercised to avoid an inappropriate diagnosis of IBD. Recurrence rates and long-term outcomes of DAC are not well defined and could range from a benign course to an overt IBD. More studies are needed in order to further characterize this entity.
憩室病（DD）是发达国家住院治疗的主要原因，影响着30%至50%的60岁以上人群。自1980年被确定为一种独特的疾病以来，憩室病相关性结肠炎（DAC）描述了在患有憩室病的结肠段中发生的黏膜炎症，直肠和近端结肠相对较少受累。其患病率约为1.3%至3.8%。发病机制是多因素的，有多项报告指出DAC与炎症性肠病（IBD）之间存在临床病理重叠，尤其是在肉芽肿性结肠炎患者中。在这种情况下，应谨慎避免对IBD进行不恰当的诊断。DAC的复发率和长期预后尚不明确，可能从良性病程到明显的IBD不等。需要更多的研究来进一步明确这一疾病。
