Ansari Mohammed Y, Mande Shekhar C
National Centre for Cell Science, Pune, India.
Front Mol Biosci. 2018 Apr 11;5:31. doi: 10.3389/fmolb.2018.00031. eCollection 2018.
Chaperonins are a subclass of molecular chaperones that assist cellular proteins to fold and assemble into their native shape. Much work has been done on Type I chaperonins, which has elucidated their elegant mechanism. Some debate remains about the details in these mechanisms, but nonetheless the roles of these in helping protein folding have been understood in great depth. In this review we discuss the known functions of atypical Type I chaperonins, highlighting evolutionary aspects that might lead chaperonins to perform alternate functions.
伴侣蛋白是分子伴侣的一个亚类，可协助细胞内蛋白质折叠并组装成其天然构象。针对I型伴侣蛋白已开展了大量研究，阐明了其精妙的机制。尽管这些机制的细节仍存在一些争议，但它们在帮助蛋白质折叠方面的作用已得到深入了解。在本综述中，我们讨论了非典型I型伴侣蛋白的已知功能，重点介绍了可能导致伴侣蛋白执行其他功能的进化方面。
