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[结节病患者的支气管肺泡灌洗——采集的方法学方面、淋巴细胞的免疫学特征及免疫球蛋白含量研究]

[Bronchoalveolar lavage in patients with sarcoidosis--methodologic aspects of the collection, immunologic characterization of lymphocytes and studies of immunoglobulin content].

作者信息

Ballin A, Bigl H, Ferner S, Fiebig H, Leonhardt P, Neubert R, Cebulla M

机构信息

Robert-Koch-Klinik, Bezirkskrankenhaus für Lungenkrankheiten Leipzig, DDR.

出版信息

Z Erkr Atmungsorgane. 1988;170(2):108-17.

PMID:2969649
Abstract

The activity of alveolitis in 25 patients with pulmonary sarcoidosis was determined by analysis of T-Lymphocytes and their subpopulations collected by broncho-alveolar lavage. The characterization of the lymphocytes was performed with monoclonal antibodies (BL-series). An amount of T-lymphocytes higher than 28% of all cells and a proportion of T4/T8-lymphocytes of 8:1 and over are signs of the activity of the alveolitis and an indication for corticoid therapy.

摘要

通过对25例肺结节病患者经支气管肺泡灌洗收集的T淋巴细胞及其亚群进行分析,测定肺泡炎的活性。使用单克隆抗体(BL系列)对淋巴细胞进行表征。T淋巴细胞数量高于所有细胞的28%以及T4/T8淋巴细胞比例达到8:1及以上是肺泡炎活性的标志,也是进行皮质类固醇治疗的指征。

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